Grants for Grad & Post-Doc Study 5th ed (Grants for Graduate and Post-Doctoral Study)
Fellowship of the « Région Ile-de-France» (18 months starting September 2010 with possibility of extension for 6-12 months). The candidate should possess a strong back-ground in molecular biology (DNA cloning, etc..).
Project : Study of O-GlcNAc glycosylation of FoxO1 the betapancreatic Cell O-GlcNAc glycosylation of cytosolic and nuclear proteins constitutes a reversible post-translational modification, analogous to phosphorylation, which now appears as a major player in the regulation of cell signalling. This modification depends on glucose concentrations, allowing a regulation of protein activities
according to the metabolic environment of the cell. O-GlcNAc modification could therefore participate in the deleterious effects associated with chronic hyperglycaemia observed in diabetes (glucotoxicty) .
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